Oral Midazolam, Selenazine and Glutathione oxidase By Noah Berkowitz [ http://www.ncbi.nlm.nih.gov/pubmed/20002087 ]
N/A
We evaluated whether 'boosting' doses of ritonavir can serve as a positive control inhibitor for pharmacokinetic drug-drug interaction studies involving cytochrome P450 3A (CYP3A). The study also determined whether 4,4-dimethyl-benziso-(2H)-selenazine (ALT-2074), an investigational organoselenium compound that acts as a catalytic mimic of glutathione oxidase, inhibits CYP3A metabolism in vivo. |
Islet cell tumor [ http://www.pancreatology.net/article/S1424-3903%2809%2980083-5/abstract ]
N/A
High PK1 mRNA levels were observed only in cultured PSCs and microdissected islet cells, but not in cancer cells, and PK1 protein was localized mainly in islets and cancer-associated stromal cells. |
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